Except for historical information contained herein, this press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995.

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"What the marketplace tells us is that men and their partners are truly taking advantage of the benefits of Cialis," said Matt Beebe, U.S. brand team leader for Cialis, Lilly ICOS LLC. "Men can take Cialis Friday evening and choose the moment for romance as late as Sunday morning. Because Cialis works for up to 36 hours, it allows a man and his partner to relax, forget about planning intimacy and let it happen when the moment is right for them." Cialis, approved by the FDA in November 2003 for the treatment of erectile dysfunction, is the only oral ED treatment shown to improve erectile function up to 36 hours in most men. The absorption of Cialis is not reduced by food, including high-fat foods.

Financial and insurance assistance

Cialis is currently available in more than 60 countries, including Australia, Brazil, Mexico, Canada, the United States and countries throughout Europe. More than two million patients worldwide have been treated with Cialis since its first introduction in February 2003. Cialis is available by prescription only and is not for everyone. Men taking nitrates, often used for chest pain, or certain alpha-blockers for prostate problems or high blood pressure, should not take Cialis. Such combinations could cause a sudden, unsafe drop in blood pressure. Such forward-looking statements are based on current expectations, estimates and projections about the industry, management beliefs and certain assumptions made by the management of ICOS and Lilly.

Aspect	Recommendation	Notes
Dosage	Take 20mg as needed, at least 30 minutes before activity	Max once per day
Food Intake	Can be taken with or without food	High-fat meals may delay effect
Alcohol Consumption	Limited intake recommended	Excessive alcohol may reduce effectiveness
Contraindications	Do not use with nitrates	Risk of severe hypotension
Missed Dose	Not applicable; take as needed	If missed, wait until next dose, do not double

Investors are cautioned that matters subject to forward-looking statements involve risks and uncertainties, including economic, competitive, governmental, technological, legal and other factors discussed in the two companies' respective filings with the Securities and Exchange Commission, which may affect the business and prospects of the two companies and Lilly ICOS.

• The mechanism for treating BPH involves relaxation of smooth muscle in the prostate and bladder.
• This reduces the dynamic component of bladder outlet obstruction.
• For ED, the mechanism involves smooth muscle relaxation in the corpus cavernosum.
• This allows for increased blood flow and trabecular smooth muscle relaxation during sexual stimulation.
• The medication does not cure ED or BPH; it manages the symptoms.
• Treatment is often part of a comprehensive management plan.
• Lifestyle changes (diet, exercise, smoking cessation) can complement pharmacotherapy.
• Underlying conditions like diabetes or hypertension should be optimally managed.
• The goal of therapy is to restore satisfactory sexual function or relieve urinary symptoms.
• Patient satisfaction surveys are used to measure treatment success.

Results and the timing and outcome of events may differ materially from those expressed or implied by the forward-looking statements in this press release.

Product	Dosage	Quantity + Bonus	Price
Cialis Generic	40mg	120 + 8 Pills	206.98€ 197.12€	Buy
Cialis Black	80mg	180 + 10 Pills	356.64€ 339.66€	Buy
Cialis Soft Tabs	20mg	270 + 10 Pills	471.40€ 448.95€	Buy
Cialis Generic	2.5mg	270 + 10 Pills	199.64€ 190.13€	Buy
Cialis Professional	20mg	360 + 6 Pills	807.03€ 768.60€	Buy
Cialis Generic	10mg	180 + 8 Pills	236.88€ 225.60€	Buy
Cialis Generic	20mg	30 + 4 Pills	68.05€ 64.81€	Buy
Cialis Professional	40mg	20 Pills	110.24€ 104.99€	Buy
Cialis Professional	40mg	10 Pills	65.09€ 61.99€	Buy
Cialis Original	20mg	34 + 2 Pills	183.99€ 175.23€	Buy
Cialis Generic	5mg	120 + 6 Pills	132.92€ 126.59€	Buy
Cialis Super Active	20mg	30 + 6 Pills	128.09€ 121.99€	Buy
Cialis Generic	60mg	60 + 4 Pills	145.06€ 138.15€	Buy

More specifically, there can be no assurance that Cialis will achieve commercial success or that competing products will not pre-empt market opportunities that might exist for the product.

Aspect	Cialis 20mg Lilly	Viagra 100mg	Levitra 20mg
Active Ingredient	Tadalafil	Sildenafil	Vardenafil
Onset of Action	30-60 minutes	30-60 minutes	30-60 minutes
Duration of Effect	Up to 36 hours	4-6 hours	Up to 12 hours
Food Interaction	Less affected by food	Affected by high-fat meals	Less affected by food
Side Effects	Headache, back pain, flushing	Headache, nasal congestion	Dizziness, muscle aches

Cialis® is a registered trademark of Lilly ICOS LLC.

How Should You Take Cialis 20 mg Tablet?

In an independent clinical study, more men selected Cialis as their preferred treatment of choice after trying different oral ED medications, primarily because of how long the drug worked.8 This may explain why many men with ED who are on oral treatment are switching to Cialis. The percentages of new prescriptions written by all doctors for oral ED treatments in April broke out as follows: Cialis, 19 percent; Levitra, 14 percent; and Viagra, 67 percent.9 "The early success of Cialis in the U.S. is similar to the trend we saw when it first became available in other countries. Cialis has claimed market shares of 19 percent to 39 percent across Europe, and even higher in some other markets," said Leonard Blum, vice president of marketing, ICOS Corporation. In the first quarter of 2004, Cialis achieved $108 million in global sales.

Higher dosages of Cialis

More than two million men around the world have been treated with Cialis since its first introduction globally last year. "For us, the number of Cialis prescriptions written by urologists is one of the most important indicators of future trends. Urologists are the experts in treating ED. We expected that urologists would be the quickest adopters of Cialis, and cialis pastile the data suggest that these specialists, like their peers overseas, are making Cialis their preferred treatment," said Blum. Cialis is changing the way doctors and patients think about treating ED by offering two important benefits: a 36-hour window of opportunity for intimacy and the ability to take the tablet on an empty stomach or with a meal, without concern that high-fat food will reduce the absorption of the medicine. All other trademarks are the property of their respective owners.

• Cialis 20mg provides a discreet and effective option for ED treatment.
• Alcohol consumption should be moderated to prevent excessive blood pressure drops.
• Cialis 20mg can be part of a broader treatment plan for sexual health.
• Patients should inform their healthcare provider of all medications before use.
• Adherence to prescribed dosage enhances safety and effectiveness.
• Cialis 20mg is not suitable for women or children.

Viagra® is a registered trademark of Pfizer, Inc.

Possible Side Effects of Cialis 20 mg Tablets

Men should discuss their health status with their doctors to ensure Cialis is right for them and that they are healthy enough for sexual activity. The most common side effects with Cialis were headache, upset stomach, delayed backache and muscle ache. Although rare, men who experience an erection for more than four hours should seek immediate medical attention. Men should not drink alcohol in excess with Cialis. Cialis studies were not designed to assess multiple intercourse attempts after a single dose.

Side effect details

ED is defined as the consistent inability to attain and maintain an erection sufficient for sexual intercourse. ED affects an estimated 152 million men and their partners worldwide.10 Experts believe that 80 - 90 percent of ED cases are related to a physical or medical condition, like diabetes, cardiovascular diseases, and prostate cancer treatment, while 10 - 20 percent are due to psychological causes.11,12 In many cases, however, both psychological and physiological factors contribute to the condition.13 Lilly ICOS LLC, a joint venture between ICOS Corporation and Eli Lilly and Company, developed tadalafil for the treatment of erectile dysfunction. Lilly, a leading innovation-driven corporation is developing a growing portfolio of first-in-class and best-in-class pharmaceutical products by applying the latest research from its own worldwide laboratories and from collaborations with eminent scientific organizations. Headquartered in Indianapolis, Ind., Lilly provides answers - through medicines and information - for some of the world's most urgent medical needs. Additional information about Lilly is available at ICOS Corporation, a biotechnology company, is dedicated to bringing innovative therapeutics to patients. The term "new treatment initiations" indicates when a physician writes out a new prescription for patients never before treated, and for patients switching from one product to another.

• Cialis 20mg can improve confidence and quality of life for men with ED.
• It’s crucial to discuss medical history with your doctor before use.
• Cialis 20mg is not a cure but a treatment to manage symptoms.
• Using Cialis 20mg as prescribed minimizes health risks.
• Emergency medical help should be sought if painful erections last too long.
• Cialis 20mg offers a convenient oral route for ED treatment.

This does not include prescriptions conveyed to pharmacies by phone or refills of existing prescriptions.

Uses of the Cialis 20 mg Tablets

Complainant having established all three elements required under the ICANN Policy, the Panel concludes that relief shall be GRANTED. Click Here to return to the main Domain Decisions Page. Click Here to return to our Home Page This release was issued by Lilly ICOS LLC Cialis Leads Market in New Treatment Initiations and Switches for April After only six months, Cialis® (tadalafil)1, the latest oral erectile dysfunction (ED) treatment on the market in the U.S., is challenging Viagra® (sildenafil citrate)2for share of the ED market as Cialis leads in new treatment initiations by urologists3 and switches from other products for April. Cialis is marketed by Lilly ICOS LLC, a joint venture between Eli Lilly and Company (NYSE: LLY) and ICOS Corporation (Nasdaq: ICOS). Cialis is the only ED treatment shown to improve erectile function up to 36 hours in most men.

How Does Cialis White work?

Cialis can be taken without regard to food. According to market research firm ImpactRx™ (which tracks the habits of a panel of high prescribing physicians and may reflect emerging trends in doctors’ offices today)4, U.S. urologists initiated treatment with Cialis in April at a rate of more than two-to-one over each of the other oral ED treatments. In fact, Cialis represented 56 percent of new treatment initiations by urologists in April, compared to 21 percent for Levitra (vardenafil HCl)5 and 23 percent for Viagra.6 Based on data from IMS, another source of market information, in April, Cialis represented 30 percent of new ED treatment prescriptions written by urologists, compared to 16 percent for Levitra and 54 percent for Viagra.7 In April, nearly two thirds of all men who switched their oral ED treatment switched to Cialis. Following is information from ImpactRx™ on share of new prescriptions written in April by doctors changing their patients' ED treatment from product to another. In this release, new treatment initiations describes data from ImpactRx only.

• Cialis 20mg is primarily used to treat erectile dysfunction in men over 18.
• It’s important to stay hydrated and avoid heavy meals before taking it.
• Cialis 20mg does not protect against sexually transmitted infections.
• The effects of Cialis 20mg last longer than many other ED medications.
• Always check for drug interactions with your healthcare provider before use.
• Do not use Cialis 20mg if you are taking medications containing nitrate.

ImpactRx™ has a panel of high prescribing physicians that recorded information on patient visits (patient identity is non-identifiable), including diagnosis and treatment.

Shipping Information

Complainant further argues that Respondent’s sale of pharmaceutical products, some of which bear the distinctive CIALIS mark, and which are the same types of products offered by Complainant, indicate that Respondent had actual knowledge of Complainant and its rights. Panels have held that constructive knowledge is not enough evidence of bad faith. See Custom Modular Direct LLC v. Custom Modular Homes Inc., FA 1140580 (Nat. 8, 2008) ("There is no place for constructive notice under the Policy.").

Tadalafil Blocks PDE5

However the Panel agrees with Complainant regarding Respondent's actual knowledge, and concludes that Respondent registered the disputed domain names in bad faith according to Policy ¶ 4(a)(iii). See Immigration Equality v. Brent, FA 1103571 (Nat. Forum Jan. 11, 2008) ("That Respondent proceeded to register a domain name identical to, and with prior knowledge of Complainant's mark is sufficient to prove bad faith registration and use under Policy ¶ 4(a)(iii)."). ImpactRx data includes new prescriptions written and refills but not prescriptions conveyed by phone.

Recommended Dosage of Cialis 20 mg Tablet

Headquartered in Bothell, Wash., ICOS is marketing its first product, Cialis (tadalafil), for the treatment of erectile dysfunction. ICOS is working to develop treatments for serious unmet medical conditions such as chronic obstructive pulmonary disease, cancer and inflammatory diseases. B-roll is available via satellite, C-band feed: WEDNESDAY, JUNE 2, 10:30 - 11:00 AM EDT C-Band, IA 6, Tr. WEDNESDAY, JUNE 2, 13:15 - 13:45 PM EDT C-Band, IA 5, Tr. THURSDAY, JUNE 3, 13:00 - 13:30 PM EDT C-Band, IA 5, Tr. ImpactRx records information from the physician perspective and not what happens at the pharmacy. Computed from IMS NPA Plus™, April 2004.

Store Type	Price per Pack (20 tablets)	Notes
Online Pharmacies	$50 - $80	Varies by seller, check for authenticity
Local Pharmacies	$70 - $100	Prices may vary regionally
Discount Programs	$45 - $65	With insurance or discounts
Bulk Purchase	$180 - $300 (for 3 packs)	Save on larger quantities