HOW IT WORKS

And if you have an HSA/FSA account, you can either use a card at checkout or download the necessary documents for reimbursement. (Wisp doesn’t accept insurance at this time, but that’s not all that unusual in the telehealth space.) Additionally, shipping is discreet and always free. However, due to the nature of Wisp’s products, the company does not accept returns or offer refunds. Only if you receive a product in error and contact Wisp within 15 days of receipt will the company investigate the situation and issue a replacement product if deemed appropriate. To learn more about Wisp and the platform’s telehealth visit process, check out our full Wisp review.

A note about sex and gender

Best prescription pill and runner-up OTC pill Oral tadalafil (generic Cialis) for women is a fairly specialized offering Libido Lift Rx should work in around 30 minutes and last 24-36 hours Prescription “pills” are actually mint-flavored tablets that dissolve under the tongue Drive For Her supplement ingredients have some supportive research Drive For Her subscriptions take 15% off 10% off prescription treatments using code INNERBODY10 Both are unsafe for those who are pregnant or breastfeeding Supplement may contain traces of all nine major allergens Supplements likely require extended use, contrary to product page information More research needed on both tadalafil and oxytocin for FSD “For Her” meds can’t ship to Alabama, California, South Carolina, Guam, or Puerto Rico Hello Cake (often stylized as just “Cake”) is a telehealth company focused on sexual health. While the brand offers a wide range of products intended to improve your sexual well-being, we chose its Cake Meds Libido Lift Rx and Hello Cake Drive For Her as our picks for the best prescription pill and runner-up OTC pill. Libido Lift Rx is unique in that it’s the first fast-acting libido-support prescription pill for women that we’ve come across, as of this writing. Most other options on the market are supplements or either prescription or non-prescription topicals. So, as mentioned previously, this dissolvable tablet may be the closest thing to an “instant” female arousal pill, since it should start working in around 30 minutes.

Exploratory Phase 2b RESPOND Study, Completed in 2023

If you’re suffering from a form of female sexual dysfunction, like hypoactive sexual desire disorder (HSDD), Libido Lift Rx will not get to the root of the problem. According to experts, HSDD appears to be caused by an imbalance of certain neurotransmitters and hormones in the brain, which the ingredients in Libido Lift Rx won’t affect.18 Pivoting to the viagra medicine supplement, Hello Cake Drive For Her (previously called “Sex Drive For Her”) is a blend of various herbal ingredients and L-arginine intended to increase sexual desire. While there is some supportive research behind most of this supplement’s ingredients, the evidence isn’t quite as strong as it is for VitaFLUX’s nitric-oxide-boosting amino acids. But, if you can’t take a supplement with such a heavy focus on increasing nitric oxide — or if you simply prefer the idea of an herbal supplement and its potential benefits — then Drive For Her is an option worth considering. (As a side note, Drive For Her only requires you to take two capsules daily instead of VitaFLUX’s six.) In addition to Libido Lift Rx and the Drive For Her supplement, it’s worth mentioning that Cake also offers a topical arousal product similar to Wisp’s OMG Cream called “O-Cream Rx for Her.” Both creams include the same 1% concentration of sildenafil (the generic form of Viagra). It’s worth mentioning that this study specifically used 3.6% sildenafil cream; smaller doses may not have as significant of an effect.9 Ergoloid mesylates, also known as “co-dergocrine mesylate,” is a medication with vasodilatory properties that’s normally used to treat cognitive impairment due to aging, but some older research has investigated it as part of a topical for the treatment of erectile dysfunction (ED).46 60 In a study from 2001, a cream containing testosterone and two “vasoactive agents” (one of which was co-dergocrine mesylate) performed better than plain testosterone cream in treating ED in older men with “low sexual interest.”47 Ultimately, while the existing data behind these ingredients appears promising, more research is needed to fully understand their potential roles in treatments for female sexual dysfunction (FSD). The chart below breaks down the cost of Wisp’s OMG!

Product	Dosage	Quantity + Bonus	Price
Viagra Original	100mg	22 + 2 Pills	120.71€ 114.96€
Viagra Generic	150mg	90 + 6 Pills	147.18€ 140.17€
Viagra Original	100mg	48 + 4 Pills	207.15€ 197.29€
Viagra Professional	100mg	360 + 6 Pills	527.09€ 501.99€
Viagra Generic	200mg	60 + 4 Pills	125.19€ 119.23€
Viagra Generic	100mg	60 + 4 Pills	96.36€ 91.77€
Viagra Original	100mg	120 + 8 Pills	470.39€ 447.99€
Viagra Generic	25mg	120 + 6 Pills	125.56€ 119.58€
Viagra Generic	200mg	270 + 10 Pills	379.76€ 361.68€
Viagra Generic	200mg	20 Pills	61.69€ 58.75€

Cream as both a one-time purchase and a subscription (charged and shipped every three months). Similar to competitors like Promescent, opting for recurring deliveries from Wisp will reduce your cost per bottle. Competitor Hello Cake offers a similar topical, O-Cream Rx For Her, that’s available in either regular (1% sildenafil) or extra strength (3% sildenafil).

Filbanserin can cause dizziness, sleepiness, nausea, and low blood pressure.
It has serious interactions with alcohol and certain medications like antifungals.
Bremelanotide side effects include nausea, vomiting, and temporary skin darkening.
Ospemifene may increase the risk of blood clots and cause hot flashes.
Testosterone therapy can cause acne, unwanted hair growth, and voice changes.
Topical estrogen has minimal systemic absorption but can cause local irritation.
All prescription treatments require a careful risk-benefit analysis with a doctor.

For example, a 12-dose order of regular strength O-Cream Rx is $108 — that’s nearly $70 more than a one-time purchase of a 15-dose bottle of OMG! And since the products from both companies contain at least 1% sildenafil, there doesn’t appear to be a dose-dependent reason for this significant price difference. Cream contains 15 treatments only if you adhere to Wisp’s instructions to use a pea-sized amount. Using any more or less than the suggested quantity can alter the number of uses you get out of a bottle — and how often you need to reorder. While Wisp’s subscriptions do net you a nice 10-15% discount, we wish the shipping intervals could be modified. Everyone’s situation is unique, and it’s not difficult to imagine someone needing refills of this cream more or less often than every quarter. And though you do have the option to request an early refill or pause your subscription as needed, it would be nice to see the company add some subscription customization options in the future to make the process more convenient from the outset for customers with different needs. When purchasing from Wisp, your telehealth visit for prescriptions — like OMG! Cream — is included with the medication cost.

Side Effect	Percentage of Users	Severity	Notes
Nausea	15%	Mild	Usually mild, transient
Headache	20%	Mild to Moderate	Common among users
Dizziness	10%	Mild	Typically subsides
Insomnia	8%	Mild	Reported in some cases

Desire Starts in the Brain...

A small 2020 double-blind, placebo-controlled study found that sildenafil cream led to “clinically significant increases in genital and self-reported measures of arousal compared to placebo cream” in six female patients. It’s worth mentioning that this study specifically used 3.6% sildenafil cream; smaller doses may not have as significant of an effect.9 Ergoloid mesylates, also known as “co-dergocrine mesylate,” is a medication with vasodilatory properties that’s normally used to treat cognitive impairment due to aging, but some older research has investigated it as part of a topical for the treatment of erectile dysfunction (ED).46 60 In a study from 2001, a cream containing testosterone and two “vasoactive agents” (one of which was co-dergocrine mesylate) performed better than plain testosterone cream in treating ED in older men with “low sexual interest.”47 Ultimately, while the existing data behind these ingredients appears promising, more research is needed to fully understand their potential roles in treatments for female sexual dysfunction (FSD). The chart below breaks down the cost of Wisp’s OMG! Cream as both a one-time purchase and a subscription (charged and shipped every three months). Similar to competitors like Promescent, opting for recurring deliveries from Wisp will reduce your cost per bottle.

Addyi (filbanserin)

Competitor Hello Cake offers a similar topical, O-Cream Rx For Her, that’s available in either regular (1% sildenafil) or extra strength (3% sildenafil). For example, a 12-dose order of regular strength O-Cream Rx is $108 — that’s nearly $70 more than a one-time purchase of a 15-dose bottle of OMG! And since the products from both companies contain at least 1% sildenafil, there doesn’t appear to be a dose-dependent reason for this significant price difference. Cream contains 15 treatments only if you adhere to Wisp’s instructions to use a pea-sized amount. Using any more or less than the suggested quantity can alter the number of uses you get out of a bottle — and how often you need to reorder.

What are other tips for boosting female sex drive?

While Wisp’s subscriptions do net you a nice 10-15% discount, we wish the shipping intervals could be modified. Everyone’s situation is unique, and it’s not difficult to imagine someone needing refills of this cream more or less often than every quarter. And though you do have the option to request an early refill or pause your subscription as needed, it would be nice to see the company add some subscription customization options in the future to make the process more convenient from the outset for customers with different needs. When purchasing from Wisp, your telehealth visit for prescriptions — like OMG! Cream — is included with the medication cost. Best prescription pill and runner-up OTC pill Oral tadalafil (generic Cialis) for women is a fairly specialized offering Libido Lift Rx should work in around 30 minutes and last 24-36 hours Prescription “pills” are actually mint-flavored tablets that dissolve under the tongue Drive For Her supplement ingredients have some supportive research Drive For Her subscriptions take 15% off 10% off prescription treatments using code INNERBODY10 Both are unsafe for those who are pregnant or breastfeeding Supplement may contain traces of all nine major allergens Supplements likely require extended use, contrary to product page information More research needed on both tadalafil and oxytocin for FSD “For Her” meds can’t ship to Alabama, California, South Carolina, Guam, or Puerto Rico Hello Cake (often stylized as just “Cake”) is a telehealth company focused on sexual health. While the brand offers a wide range of products intended to improve your sexual well-being, we chose its Cake Meds Libido Lift Rx and Hello Cake Drive For Her as our picks for the best prescription pill and runner-up OTC pill. Libido Lift Rx is unique in that it’s the first fast-acting libido-support prescription pill for women that we’ve come across, as of this writing.

Research is ongoing into new drug targets, like melanocortins and oxytocin.
Lybrido and Lybridos were combination drugs (testosterone/sildenafil) investigated.
The EROS-CTD device is an example of a non-hormonal, device-based treatment.
Gene therapy and other novel approaches are in very early stages of research.
Future treatments may offer more personalized approaches based on individual biology.
Digital therapeutics and app-based cognitive behavioral therapy are emerging.
The field is moving towards treating the combined psychological and biological causes.

Most other options on the market are supplements or either prescription or non-prescription topicals.

Off-Label Use	Potential Risks	Medical Advice
Sildenafil for Female Libido	Cardiovascular side effects, interactions with other meds	Always consult a doctor before use
Non-approved supplements	Unknown composition, higher risk of adverse reactions	Use only if prescribed by a healthcare professional
DIY formulations	Dangerous, no clinical testing	Highly discouraged

So, as mentioned previously, this dissolvable tablet may be the closest thing to an “instant” female arousal pill, since it should start working in around 30 minutes. If you’re suffering from a form of female sexual dysfunction, like hypoactive sexual desire disorder (HSDD), Libido Lift Rx will not get to the root of the problem. According to experts, HSDD appears to be caused by an imbalance of certain neurotransmitters and hormones in the brain, which the ingredients in Libido Lift Rx won’t affect.18 Pivoting to the viagra medicine supplement, Hello Cake Drive For Her (previously called “Sex Drive For Her”) is a blend of various herbal ingredients and L-arginine intended to increase sexual desire. While there is some supportive research behind most of this supplement’s ingredients, the evidence isn’t quite as strong as it is for VitaFLUX’s nitric-oxide-boosting amino acids.

If you're tired of uncertain quality and unproven options, you're not alone.

Participants in the treatment group (600mg per day for eight weeks) experienced a “significant increase” in free testosterone and estradiol, as well as sexual arousal and desire versus the placebo group.73 Other, unrelated research on fenugreek extract found similar results. A 2021 study gave 48 healthy, menstruating women either 250mg of fenugreek extract twice a day or a placebo. Those who took the extract had fewer sexual problems and reduced irritability, along with increased estradiol, free testosterone, and total testosterone.74 The evidence on reishi mushrooms for female sexual dysfunction or libido support is pretty slim, with only a couple of animal studies available at this time. In a 2018 study, male Wistar rats were either given one of two reishi extracts (150mg/kg and 300mg/kg) or one of two placebos (sildenafil and distilled water) to evaluate the mushroom’s aphrodisiac potential. Results showed that the lower dose of 150mg/kg was more effective, but, in general, the reishi extract increased the rats’ interest in females and led to increased mounting behavior and mating performance.75 A similar male rat study from 2022 found that reishi mushroom polysaccharides may be able to treat diabetes mellitus-induced erectile dysfunction (DMED), in part by enhancing “the mRNA expression of” nitric oxide synthase (the enzyme that turns L-arginine to L-citrulline and nitric oxide).76 77 This ingredient has the least amount of scientific support.

Let's do it.

Though you cannot place an order quite yet...

But, if you can’t take a supplement with such a heavy focus on increasing nitric oxide — or if you simply prefer the idea of an herbal supplement and its potential benefits — then Drive For Her is an option worth considering.

Filbanserin typically takes 4-8 weeks of daily use to show any potential effect.
Bremelanotide is used as needed, with an injection approximately 45 minutes before sex.
Effects of a single Vyleesi injection are intended to last for about 8-12 hours.
Ospemifene is a daily tablet that requires ongoing use to maintain its effects.
Topical estrogen treatments often show improvement in dryness within a few weeks.
Testosterone therapy may take several months to potentially influence libido.
Psychological therapies require a longer-term commitment for sustainable results.

(As a side note, Drive For Her only requires you to take two capsules daily instead of VitaFLUX’s six.) In addition to Libido Lift Rx and the Drive For Her supplement, it’s worth mentioning that Cake also offers a topical arousal product similar to Wisp’s OMG Cream called “O-Cream Rx for Her.” Both creams include the same 1% concentration of sildenafil (the generic form of Viagra).

Filbanserin (Addyi) is not available on the standard NHS drug tariff.
Vyleesi (Bremelanotide) is also not routinely funded by the NHS in the UK.
Ospemifene (Senshio) may be prescribed on the NHS for specific menopausal symptoms.
Testosterone is used off-label, and funding can vary by local Clinical Commissioning Group.
Most treatments for FSD are primarily accessed through private prescription.
Private consultation costs range from £50-£250, plus the cost of medication.
Some private health insurance policies may cover specialist consultations and treatments.

DARE to PLAY Sildenafil Cream

At this time, we’d only recommend opting for Cake’s O-Cream Rx for Her if you’ve tried a 1% sildenafil topical, found it wasn’t strong enough for your needs, and would like to try the 3% sildenafil extra strength variety. That said, let’s examine the ingredients in Libido Lift Rx and Drive For Her. Libido Lift Rx has a fairly small list of ingredients, containing only L-citrulline, oxytocin, and tadalafil. Let’s cover how this prescription’s inclusions work. The research on tadalafil for women is pretty sparse, but the results that exist are promising. As noted in a 2017 review on phosphodiesterase type 5 (PDE5) inhibitors for FSD in older women,70 research has mainly focused on tadalafil for women with FSD due to antidepressants or diabetes.71 72 Both studies (using 5-20mg tadalafil) led to positive outcomes — all patients experienced improvement — but were limited by small sample sizes and lack of placebo control.

Get on the List

As researchers continue to investigate the effects of PDE5 inhibitors in women, we’ll update this guide accordingly. Since L-citrulline gets converted in the body to L-arginine and nitric oxide, supplementing with this amino acid may lead to increased nitric oxide production.10 There really isn’t any research on oral L-citrulline supplementation alone for female sexual dysfunction or libido support, but some research on men found that 1,500mg could help treat mild to moderate erectile dysfunction.20 However, that’s nearly eight times the amount in Libido Lift Rx. But, to be fair, the L-citrulline in this prescription appears to play more of a supporting role than a main one. There’s very little research on oxytocin as a treatment for sexual dysfunction. One small study from 2015 found that long-term (eight weeks) intranasal oxytocin (32UI) self-administered by women 50 minutes before sexual intercourse improved both sexual function and symptoms of depression.68 And a 2023 study in men receiving testosterone treatment for erectile dysfunction found that oxytocin troches (50-100UI) may be a helpful adjunctive treatment, with 56% of patients (14 out of 26) considered responders to the intervention.69 In contrast to the short ingredient list of Libido Lift Rx, Drive For Her contains seven herbal ingredients and one amino acid. Here’s how their potential benefits for female sexual health break down. A 2015 study evaluated how Libifem affected sex hormones and sexual function in 80 healthy, menstruating women with self-reported low libido. Participants in the treatment group (600mg per day for eight weeks) experienced a “significant increase” in free testosterone and estradiol, as well as sexual arousal and desire versus the placebo group.73 Other, unrelated research on fenugreek extract found similar results. A 2021 study gave 48 healthy, menstruating women either 250mg of fenugreek extract twice a day or a placebo. Those who took the extract had fewer sexual problems and reduced irritability, along with increased estradiol, free testosterone, and total testosterone.74 The evidence on reishi mushrooms for female sexual dysfunction or libido support is pretty slim, with only a couple of animal studies available at this time. In a 2018 study, male Wistar rats were either given one of two reishi extracts (150mg/kg and 300mg/kg) or one of two placebos (sildenafil and distilled water) to evaluate the mushroom’s aphrodisiac potential.

We got busy with a full clinical study.

However, Cake’s prescription is more expensive than Wisp’s for fewer applications. But, unlike Wisp, Cake does offer an extra strength option containing 3% sildenafil, though that’s even pricier. At this time, we’d only recommend opting for Cake’s O-Cream Rx for Her if you’ve tried a 1% sildenafil topical, found it wasn’t strong enough for your needs, and would like to try the 3% sildenafil extra strength variety. That said, let’s examine the ingredients in Libido Lift Rx and Drive For Her. Libido Lift Rx has a fairly small list of ingredients, containing only L-citrulline, oxytocin, and tadalafil.

Effects on sexual dysfunction

Let’s cover how this prescription’s inclusions work. The research on tadalafil for women is pretty sparse, but the results that exist are promising. As noted in a 2017 review on phosphodiesterase type 5 (PDE5) inhibitors for FSD in older women,70 research has mainly focused on tadalafil for women with FSD due to antidepressants or diabetes.71 72 Both studies (using 5-20mg tadalafil) led to positive outcomes — all patients experienced improvement — but were limited by small sample sizes and lack of placebo control. As researchers continue to investigate the effects of PDE5 inhibitors in women, we’ll update this guide accordingly. Since L-citrulline gets converted in the body to L-arginine and nitric oxide, supplementing with this amino acid may lead to increased nitric oxide production.10 There really isn’t any research on oral L-citrulline supplementation alone for female sexual dysfunction or libido support, but some research on men found that 1,500mg could help treat mild to moderate erectile dysfunction.20 However, that’s nearly eight times the amount in Libido Lift Rx.

What happens when females take Viagra?

But, to be fair, the L-citrulline in this prescription appears to play more of a supporting role than a main one. There’s very little research on oxytocin as a treatment for sexual dysfunction. One small study from 2015 found that long-term (eight weeks) intranasal oxytocin (32UI) self-administered by women 50 minutes before sexual intercourse improved both sexual function and symptoms of depression.68 And a 2023 study in men receiving testosterone treatment for erectile dysfunction found that oxytocin troches (50-100UI) may be a helpful adjunctive treatment, with 56% of patients (14 out of 26) considered responders to the intervention.69 In contrast to the short ingredient list of Libido Lift Rx, Drive For Her contains seven herbal ingredients and one amino acid. Here’s how their potential benefits for female sexual health break down. A 2015 study evaluated how Libifem affected sex hormones and sexual function in 80 healthy, menstruating women with self-reported low libido. Results showed that the lower dose of 150mg/kg was more effective, but, in general, the reishi extract increased the rats’ interest in females and led to increased mounting behavior and mating performance.75 A similar male rat study from 2022 found that reishi mushroom polysaccharides may be able to treat diabetes mellitus-induced erectile dysfunction (DMED), in part by enhancing “the mRNA expression of” nitric oxide synthase (the enzyme that turns L-arginine to L-citrulline and nitric oxide).76 77 This ingredient has the least amount of scientific support.

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