Some ED medications are not suitable for men with certain medical conditions, and your doctor can advise you on an alternative. Call your doctor immediately if you experience dizziness or feel nauseous during sexual activity, or develop pain, numbness, or tingling in your chest, arms, neck, or jaw. Do not take sildenafil if you are also taking a nitrate drug (such as nitroglycerin or isosorbide dinitrate/mononitrate) for chest pain or heart problems. Do not take sildenafil with recreational drugs such as "poppers". Taking these substances together can cause a sudden and dangerous drop in blood pressure. Always buy your ED medications from a reputable supplier as there are a lot of counterfeit products on the market.
| Country | Approval Status | Regulatory Agency | Notes |
|---|---|---|---|
| USA | Approved | FDA | For ED and pulmonary hypertension |
| European Union | Approved | EMA | Similar indications |
| India | Approved | CDSCO | Generic versions available |
| Australia | Approved | TGA | Prescription required |
Certain lifestyle and psychological factors, such as smoking, drinking, and stress, can impact ED.
Side Effects
High levels of PDE-5 are found in the penis, lungs, and retina. PDE-5 is also found throughout the body within the smooth muscle cells of the blood vessels and muscles. Sildenafil belongs to the drug class called phosphodiesterase (PDE) type 5 inhibitors. Sildenafil (Viagra, Vybrique brands and generic) is used to treat erectile dysfunction (ED, impotence). It increases blood flow to the penis following sexual stimulation by blocking the enzyme responsible for the breakdown of cGMP.
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This allows men to keep an erection hard enough for sex. Sildenafil (Viagra, Vybrique brands and generic) only works following sexual stimulation. It works within 30 to 60 minutes, but may be taken up to four hours before sexual activity. Sildenafil (Revatio brand) reduces high blood pressure associated with pulmonary arterial hypertension (PAH). This improves the ability to exercise in people with PAH and delays any worsening of their symptoms. Eliminating these - for example, staying more active, losing weight if you are overweight, reducing alcohol intake, stopping smoking, and reducing stress - may also help improve ED. Never take other ED medications at the same time as taking sildenafil.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Viagra Generic | 50mg | 60 + 4 Pills | 83.93€ 79.93€ | |
| Kamagra | 100mg | 12 Pills | 55.64€ 52.99€ | |
| Viagra Generic | 100mg | 120 + 6 Pills | 149.50€ 142.38€ | |
| Viagra Generic | 50mg | 180 + 8 Pills | 158.82€ 151.26€ | |
| Kamagra Soft Tabs | 100mg | 32 Pills | 120.11€ 114.39€ | |
| Viagra Generic | 150mg | 180 + 10 Pills | 236.46€ 225.20€ | |
| Viagra Generic | 50mg | 360 + 10 Pills | 225.33€ 214.60€ | |
| Viagra Generic | 150mg | 20 Pills | 55.02€ 52.40€ | |
| Kamagra Soft Tabs | 100mg | 60 + 4 Pills | 180.59€ 171.99€ | |
| Viagra Generic | 50mg | 120 + 6 Pills | 129.64€ 123.47€ | |
| Kamagra | 100mg | 120 + 6 Pills | 330.74€ 314.99€ | |
| Viagra Generic | 200mg | 10 Pills | 40.96€ 39.01€ | |
| Viagra Generic | 25mg | 20 Pills | 37.74€ 35.94€ |
Do not take Viagra while taking Revatio and vice-versa. Seek urgent medical advice if an allergic reaction, sudden vision loss, or painful erections lasting more than four hours occur.
What happens if I overdose?
May not be suitable for some people including those with angina, chest pain, other heart conditions, liver or kidney problems, blood or bleeding disorders, stomach ulcers, certain eye conditions, or a physical deformity of the penis (such as Peyronie's disease). Higher dosages of sildenafil are associated with a higher risk of death in children with PAH. For this reason, the FDA does not recommend use in children aged less than 18 years. May interact with some medications including certain antibiotics and antifungals, herbal remedies, HIV medicines, nitrates, and drugs used in the treatment of high blood pressure or prostate disorders. Sildenafil should not be taken with other PDE-5 inhibitors.
Off-Label Use and Dosage (Pediatric)
The dosage may need to be reduced in people with kidney or liver disease. More research is needed to establish if sildenafil has a role in sexual dysfunction in women. Sildenafil offers no protection against sexually transmitted diseases. Note: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. Sildenafil is used to treat erectile dysfunction (ED) (Viagra, Vybrique brands, generic) and to reduce blood pressure in pulmonary arterial hypertension (PAH) (Revatio brand). Drinking alcohol after taking sildenafil may lower blood pressure and decrease sexual performance. If you are a woman of childbearing age taking sildenafil (brand Revatio) for PAH, then tell your doctor if you become pregnant or are intending to become pregnant. It is not known if sildenafil is distributed into breast milk. Peak plasma concentrations of sildenafil are reached within 30 to 120 minutes of a single dose.
More about sildenafil
When used to treat PAH, sildenafil is available as tablets (20 mg) for and an IV injection. When used for ED, sildenafil is available as oral tablets of 25 mg, 50 mg, and 100 mg strengths, or an oral film (Vybrique brand) of 25 mg, 50 mg, 75 mg, and 100 mg strengths. If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include: Dyspepsia, flushing, headache, indigestion, muscle or back pain, and visual disturbances are the most common side effects reported. Other side effects include a drop in blood pressure, insomnia, nasal congestion, or a runny nose and nosebleeds. Sudden hearing loss has also been reported.
Elderly Precautions
Some people taking sildenafil have had bleeding events; however, it has not been established if this is related to sildenafil use. Rarely, may decrease blood flow to the optic nerve causing sudden vision loss. The risk is greater in people aged older than 50, with diabetes, heart disease, high blood pressure, high cholesterol, who smoke, or with certain pre-existing eye problems. Rarely, may cause other side effects or lead to painful erections lasting longer than four hours. See your doctor immediately if this happens. Effects of sildenafil, when used for ED, are usually noticeable within 30 to 60 minutes of a single dose. When used to treat PAH, blood pressure-lowering effects are noticeable within one to two hours. Medicines that interact with sildenafil may either decrease its effect, affect how long it works, increase side effects, or have less of an effect when taken with sildenafil. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. Speak to your doctor about how drug interactions should be managed. Sildenafil is metabolized mainly by CYP3A4 and to some extent by CYP2C9.
Ongoing Research and Future Applications
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Phonetic Name
Sildenafil is used to treat erectile dysfunction (ED) in men or pulmonary arterial hypertension (PAH) in both men and women, depending on the brand. Viagra and Vybrique are used for ED and Revatio is used for PAH. Sildenafil works by blocking the action of an enzyme called cGMP-specific phosphodiesterase type-5 (PDE-5). This enzyme breaks down cGMP, a substance that induces smooth muscles to relax. Blocking PDE-5 means increased levels of cGMP within the smooth muscles which promotes muscle relaxation and vasodilation (a widening of blood vessels). It also weakly inhibits CYP1A2, 2C(, 2C19, 2D^, 2E1, and 3A4.
- Some users report headaches and dizziness after taking sildenafil.
- A common side effect is facial flushing and nasal congestion.
- Rare side effects include sudden hearing loss or vision loss.
- Priapism requires urgent medical attention to prevent tissue damage.
- Sudden vision loss should be immediately evaluated by a doctor.
- Allergic reactions such as rash, hives, or swelling are possible.
- Discontinue use and seek medical help if serious side effects occur.
Any drug that is a substrate of one of these enzymes could potentially interact with sildenafil. In addition, taking sildenafil with too much alcohol can lead to orthostatic hypotension, which is a drop in blood pressure when you go from a sitting or lying down position to standing.
| Property | Description | Value | Units |
|---|---|---|---|
| Molecular Weight | The mass of one mole of sildenafil citrate | 474.58 | g/mol |
| Chemical Formula | Molecular composition | C22H30N6O4S | |
| Solubility | Water solubility | Slightly soluble | at 25°C |
| pH of Solution | Typical pH when dissolved in water | 3.8 - 4.2 | |
| Melting Point | The temperature at which it melts | 196 - 198 | °C |
Symptoms include a headache, dizziness, or fainting when standing. Antacids, such as magnesium hydroxide or aluminum hydroxide may also affect the absorption of sildenafil. Grapefruit juice may also increase the side effects of sildenafil. Note that this list is not all-inclusive and includes only common medications that may interact with sildenafil. You should refer to the prescribing information for sildenafil for a complete list of interactions. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use sildenafil only for the indication prescribed. Sildenafil Citrate is a medication that has gained significant attention in the medical community for its versatile applications. It is known by several brand names, including Revatio and Viagra[2].
Administration and Monitoring
It is taken when needed for ED approximately 1 hour before sexual stimulation (maximum dose once daily) and daily for PAH. A headache, stomach upsets, and flushing are the main side effects, and it should not be taken within 24 hours of a nitrate. If you are taking sildenafil (Viagra, Vybrique) for ED, do sildenafil citrate 200mg price not take it more than once a day. Take an hour before sexual stimulation (range 30 minutes to 4 hours). If you take it with a high-fat meal it may delay how quickly it starts working.
Revatio Injection
Place sildenafil film on your tongue and allow it to dissolve. If you are taking sildenafil (Revatio) for PAH, take it as directed (the usual dosage is three times daily). You can take it either with or without food. Do not consume grapefruit or grapefruit products while taking sildenafil. Always talk to your doctor before taking ANY medication for ED. This drug belongs to a class of medications called phosphodiesterase type 5 (PDE5) inhibitors, which work by affecting specific enzymes in the body[3]. Sildenafil Citrate is primarily used to treat two main conditions: Pulmonary Arterial Hypertension (PAH): This is a serious condition where there is high blood pressure in the arteries that supply the lungs. Sildenafil helps to improve exercise capacity and slow down the worsening of this condition[1]. Erectile Dysfunction (ED): While not the focus of most clinical trials presented, Sildenafil is well-known for its use in treating erectile dysfunction in men[4].
- Sildenafil citrate may cause a drop in blood pressure.
- Do not consume large quantities of grapefruit juice while on sildenafil.
- Pregnant or breastfeeding women should not use sildenafil without guidance.
- The drug does not improve libido, only facilitates blood flow.
- It is not intended for recreational use or enhancement.
- Psychological factors can also affect the efficacy of sildenafil.
- Regular medical check-ups are recommended for long-term users.
This action leads to the relaxation of blood vessels, which improves blood flow in specific areas of the body. In the case of PAH, it helps to reduce blood pressure in the lungs, while for ED, it increases blood flow to the penis[3]. Sildenafil Citrate comes in various forms and dosages: Tablets: Available in different strengths, commonly 20 mg for PAH and 50 mg or 100 mg for ED[5]. Oral Suspension: A liquid form of the medication, typically at a concentration of 10 mg/mL[6]. Orally Disintegrating Film (ODF): A newer form that dissolves in the mouth[2]. The dosage and frequency of administration depend on the condition being treated and the individual patient’s needs.